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Water → N-alpha-t-Butyloxycarbonyl-L-biphenylalanine (Boc-L-Bip-OH)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoate | HCID 2736832 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | N-alpha-t-Butyloxycarbonyl-L-biphenylalanine (Boc-L-Bip-OH) | HCID 2761796 | — |
反応手順
(S)-2-(t-butoxycarbonylamino-3-(biphenyl-4-yl)-propionic acid methyl ester (4.1 g, 11.5 mmol) is dissolved at room temperature in methanolic 1N sodium hydroxide (60 mL). The solution is stirred for 3 hours. Ether (30 mL) and water (30 mL) are added. The aqueous layer is separated and acidified with concentrated hydrochloric acid, then extracted with ether (2×20 mL) and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gives (S)-2-(t-butoxycarbonylamino)-3-(biphenyl-4-yl)-propionic acid as a white solid, m.p. 122°-123°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05250522 |
| 出典データセット | uspto-grants-1993_10 |
| ORD ID | ord-db66ccf862ca4008bdc7f35329cba1e5 |
| 出典メモ | uspto-grants-1993_10 |