Sodium Hydroxide → HCID 178494642, compound

HRID 1655482Notes

Reaction equation

HRID 1655482 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[C:7]2[C:27]([C:31]([O:33]C)=[O:32])=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1.[OH-].[Na+]>CO.O>[CH3:1][O:2][CH2:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:14][CH:15]=2)[C:7]2[C:27]([C:31]([OH:33])=[O:32])=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 178494643HCID 178494643, compound

Product 1

HCID 178494642HCID 178494642, compoundYield 82.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of methyl 2-methoxymethyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate (0.2 g) in methanol (10 ml) and 1N-NaOH (1.5 ml) was heated at 80° C. for 20 hours. The solution was concentrated to dryness to give a residue. The residue was dissolved in H2O and made acidic to give a crystalline product. Recrystallization from DMF-MeOH-H2O gave colorless prisms (0.16 g, 80%).

Workup

  1. concentrationThe solution was concentrated to dryness
  2. customto give a residue
  3. customto give a crystalline product
  4. customRecrystallization from DMF-MeOH-H2O

Sources & evidence

ORD record
ord-b63c75e73e3f4c1f87fee8855ccda57a
Source dataset
uspto-grants-1993_10
Patent number
US05250554

Reaction notes

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