Thionyl Chloride → HCID 178468761, compound

Participants

Reaction Steps

To a solution of ethyl 2-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate (0.2 g) in CH2Cl2 (3 ml) was added thionyl chloride (0.3 ml) dropwise and the mixture was refluxed for 3 hours. The reaction solution was poured into ice-water and the organic layer was washed with water, dried and evaporated to dryness to give a pale yellow amorphous powder (0.2 g, 96%).

Provenance & Evidence