Benzyl acetone → HCID 19792535, compound

Participants

Reaction Steps

Using ethyl cyclohexane carboxylate (63 g, 0.4 mol) and 4-phenyl-2-butanone (20 g, 0.13 mol), the reaction was carried out in the same manner as described in Example 2, (1) and crude dark orange oil (23 g) was chromatographed on silica gel (Wako Gel C-200) eluting with n-hexane/ethyl acetate (100:1→100:2→100:3) to afford the title compound as a yellow oil which was an ca 3:17 mixture of Keto/Enol by the methylene singlet at δ3.55 ppm and the methine singlet at δ5.45 ppm in the 1HNMR spectrum; yield: 2.5 g.

Provenance & Evidence