4'-(Aminomethyl)-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester → HCID 19791899, compound

Participants

Reaction Steps

t-Butyl 4'-aminomethyl-biphenyl-2-carboxylate from Example 11A is reacted, by the method described in Example 1C, with ethyl 2-n-butyl-4-chloropyrimidine-5-carboxylate (0.40 g, 1.65 mmol) to give 2-n-butyl-4-{N-[(2'-t-butoxycarbonyl-biphenyl-4-yl)methyl]amino]-5-carboethoxypyrimidine. The t-butyl protecting group is removed by treatment with trifluoroacetic acid in methylene chloride at ambient temperature to afford the title compound.

Provenance & Evidence