Acetic Acid → HCID 178441650, compound

HRID 1655565Notes

Reaction equation

HRID 1655565 reaction equation
[CH2:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[NH:29][N:28]=[N:27][N:26]=3)=[CH:15][CH:14]=2)[C:8]([C:30]#[N:31])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4].C(O)(=[O:34])C>[OH-].[K+]>[CH2:1]([C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[NH:29][N:28]=[N:27][N:26]=3)=[CH:17][CH:18]=2)[C:8]([C:30]([NH2:31])=[O:34])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 178441648HCID 178441648, compound

Product 1

HCID 178441650HCID 178441650, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

2-Butyl-4-{N-[(2'-[1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carbonitrile, the product of Example 14, is heated in dilute aqueous potassium hydroxide. Neutralization with acetic acid affords the title compound.

Sources & evidence

ORD record
ord-1d566a9c2fe94848a92b84412a4dee8b
Source dataset
uspto-grants-1993_10
Patent number
US05250548

Reaction notes

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