HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 19791767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | 2-(4-Methylphenoxy)benzoic acid | HCID 578656 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 19791767 | HCID 19791767 | — |
Reaction Steps
2-[4-Methylphenoxy]benzoic acid, prepared as described by D. J. Carini in J. Medicinal Chem., 33, 1330- (1990), is converted to the corresponding acid chloride with phosphorous trichloride in benzene. The acid chloride is reacted with ammonia to give 2-(4-methylphenoxy)-benzenecarboxamide. The carboxamide is then dehydrated by treatment with thionyl chloride to give 2-(4'-methylphenoxy)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05250548 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-70d04633e6cc4fab980bc9d02462bbca |
| Source note | uspto-grants-1993_10 |