Sulfuric Acid → HCID 14856650, compound

Participants

Reaction Steps

A mixture of 2.12 g (4 RS, 5 R)-1,3-dibenzyl-2-oxo-5-(4-oxo-4-phenyl-2-thiabutyl)imidazolidin-4-ol (prepared according to Example 3) and 100 ml of ethanol is brought to pH 3.1 (against Methyl Orange) at 0°-5° C. using 2 normal sulfuric acid in ethanol. After stirring at 0°-5° C. for two hours, the mixture is brought to pH 5 to 6 using 2% potassium hydroxide in ethanol. After customary working-up and flash chromatography, 2.043 g (91% of theory) of (4 RS, 5 R)-1,3-dibenzyl-2-oxo-5-(4-oxo-4-phenyl-2-thiabutyl)-4-ethoxyimidazolidine, Rf =0.69 (EtOAc/hexane 3:7), are obtained. The following are oxo-7-(methoxycarbonyl)-2-thiaheptyl)-4-ethoxyimidazolidine, yield 85% of theory, Rf =0.62 (EtOAc/hexane 1:1),

Provenance & Evidence