Hexafluoroacetone → HCID 10040634, compound

Participants

Reaction Steps

This compound was prepared from epibromohydrin and hexafluoroacetone (HFA) (1:1 mole ratio) in the presence of catalytic amounts of tetrabutylammonium bromide and water at 125° C. in 95% isolated yield. Compound 7 has a boiling point 56° C./2 mm. 1H NMR (neat): δ 4.88 (m, 1H), 4.73 (t, J=7.5 Hz, 1H), 4.22 (t, J=7.5 Hz, 1H), 3.60 (m, 2H); 19F NMR (neat: -80.5 (q, J=8.5 Hz, 3F), -81.0 (q, J=8.5 Hz, 3F). Anal. Calc. for C6H5BrF6O2 : C: 23.78, H: 1.66, Br: 26.37, F: 37.62; Found; C: 23.91, H: 1.64, Br: 26.87, F: 37.84.

Provenance & Evidence