HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Hydroxy-4-[(2-tert.-butoxycarbonylaminoacetyl)amino]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-(tert-butoxycarbonyl)glycine | HCID 78288 | — |
| Reactant | 4-Amino-3-hydroxybenzoic acid | HCID 137566 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Hydroxy-4-[(2-tert.-butoxycarbonylaminoacetyl)amino]-benzoic acid | HCID 15611019 | — |
Reaction Steps
A solution of 9.75 g of 4-amino-3-hydroxybenzoic acid and 9.75 ml of triethylamine in 90 ml of dimethylformamide is heated to 80° C. 20 g of the N-hydroxysuccinimide ester of N-tert.-butoxycarbonylglycine are added and the reaction mixture is kept at 80° C. for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05250725 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-1e9a4f6b54304a0091ee0d4c18de1e18 |
| Source note | uspto-grants-1993_10 |