Methane → HCID 6516121, compound

Participants

Reaction Steps

4.1 g of dimethylamine hydrochloride, 3.7 g of paraformaldehyde and 20 ml of ethanol were added with 5 drops of concentrated hydrochloric acid to 7.6 g of 2-(E)-pentylidene cyclopentanone. After refluxing for about 2 hours, the resulting solution was mixed with 2.2 g of paraformaldehyde and then refluxed for about 2 additional hours. The solution was treated with activated charcoal and filtered. The filtrate was allowed to stand overnight, filtered and washed with cold ether containing a small amount of absolute ethanol to give 7.7 g of 2-Dimethylaminomethyl-5-(E)-pentylidene cyclopentanone hydrochloride as colorless leaflets. The melting point of the product was determined to be 156°-157° C.

Provenance & Evidence