HCID 178456023, compound → HCID 178456024, compound

Participants

Reaction Steps

1.3 g of fluoren-9-ylmethyl [(S)-1-[[(1S,2S,4S)-2-hydroxy-1-isobutyl-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol-4-ylethyl]carbamate in 30 ml of methylene chloride and 2 ml of piperidine were stirred at room temperature for 1.5 hours. Thereafter, the solvent was evaporated and the residue was triturated with hexane. The (S)-α-amino-N-[(1S,2S,4S)-2-hydroxy-1-isobutyl-4-isopropyl-5-hexenyl]-imidazole-4-propionamide so obtained was used in the next step without further purification.

Provenance & Evidence