HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 13242795, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | O-Benzylhydroxylamine | HCID 102313 | — |
| Reactant | HCID 10921701 | HCID 10921701 | — |
| Reactant | HCID 19790783 | HCID 19790783 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13242795 | HCID 13242795 | — |
Reaction Steps
In a manner analogous to that described for α-benzyltetrahydro-β-oxo-4H-1,4-oxazinepropionic acid, benzylmalonic acid monomethyl ester was amidated with O-benzylhydroxylamine and the resulting product [MS: 314 (M+H)+ ] was saponified with 1N sodium hydroxide solution in a 9:1 mixture of methanol and water to the corresponding acid. Recrystallization of the crude product from methanol/methylene chloride/ether yielded α-[(benzyloxy)carbamoyl]hydrocinnamic acid of melting point 147°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05250517 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-eeeedf7302924a81adf636345cd0960c |
| Source note | uspto-grants-1993_10 |