HCID 178456025, compound → HCID 178455997, compound

Participants

Reaction Steps

150 mg of (S)-α-[(RS)-α-[(benzyloxy)carbamoyl]-hydrocinnamamido]-N-[(1S,2S,4S)-1-cyclohexyl-2-hydroxy 4-isopropyl-5-hexenyl]imidazole-4-propionamide were hydrogenated in the presence of 5% palladium on carbon in methanol for 3 hours. After completion of hydrogen uptake, the catalyst was filtered and the filtrate was evaporated. Recrystallization of the residue from methanol/methylene chloride/ether yielded (S)-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-4-ethyl-2-hydroxy-5-methylhexyl]-α-[(RS)-α-(hydroxycarbamoyl)hydrocinnamamido]imidazole-4-propionamide as white crystals of melting point 123°.

Provenance & Evidence