反应详情

50 mg of (S)-α-amino-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]imidazole-4-propionamide were dissolved in 3 ml of methanol and hydrogenated at room temperature for 3 hours at normal pressure in the presence of 7 mg of palladium-on-carbon. Thereafter, the catalyst was filtered off and rinsed with methanol. The alcoholic solution was then evaporated under reduced pressure, to obtain (S)-α-amino-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropylhexyl]imidazole-4-propionamide as a colorless foam. MS: 393 (M+H)+.

1. filtrationThereafter, the catalyst was filtered off
2. washrinsed with methanol
3. customThe alcoholic solution was then evaporated under reduced pressure