Acetate-hydrochloric acid → HCID 178455999, compound

Participants

Reaction Steps

100 mg (0.13 mmol) of t-butoxycarbonyl [2-[(RS)-3-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]- 2 imidazol-4-ylethyl]carbamoyl]-4-phenylbutyramido]ethyl]glycine t-butyl ester were dissolved in 2 ml of acetic acid and stirred at room temperature for 3 hours with 4 ml of 1N hydrochloric acid/acetic acid. Thereafter, the reaction mixture was evaporated under reduced pressure and the residue was digested with ether and filtered off, to give N-[2-[(RS)-3-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol 4-ylethyl]carbamoyl]-4-phenylbutyramido]ethyl]glycine dihydro chloride as a powder, MS: 681 (M+H)+.

Provenance & Evidence