HCID 178525808, compound → HCID 178525809, compound

Participants

Reaction Steps

3.2 g (6.83 mmol) of (S)-α-(dibenzylacetoxy)imidazole-4-propionic acid benzyl ester in 150 ml of methanol were hydrogenated at room temperature for 2 hours in the presence of 660 mg of palladium-on-carbon. The catalyst was filtered off and the filter residue was washed several times with a 1:1 mixture of methylene chloride and methanol. The solution was concentrated under reduced pressure until crystallization occurred. Recrystallization of the crystallizate from methylene chloride/methanol yielded 2.5 g (96%) of (S)-α-(dibenzylacetoxy)imidazole-4-propionic acid, melting point 210°.

Provenance & Evidence