Ammonia → HCID 178456006, compound

Participants

Reaction Steps

A solution of 100 mg of ethyl (R)-3-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]-4-phenylbutyrate in 30 ml of methanol was saturated with ammonia for 1-2 minutes and subsequently left to stand at room temperature for 12 hours. Thereafter, the solvent was removed under reduced pressure and the residue was chromatographed on silica gel with 10% methanol in methylene chloride as the eluting agent, to obtain 63 mg (66%) of (S)-α-[(R)-α-(carbamoylmethyl)hydrocinnam-amido]-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]imidazole-4-propionamide as a resin. MS: 580 (M+H)+.

Provenance & Evidence