Dimethylamine → HCID 178456015, compound

Participants

Reaction Steps

80 mg (0.13 mmol) of ethyl (R)-3-[[(S)-1-[[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]carbamoyl]-2-imidazol-4-ylethyl]carbamoyl]-4-phenylbutyrate were taken up in 2 ml of a 5.6 molar alcoholic dimethylamine solution and heated to reflux for 3 hours. The solution was then evaporated and the residue was chromatographed on silica gel with a 20:1 mixture of methylene chloride and methanol to obtain 33 mg (20%) of (S)-N-[(1S,2S,4S)-1-(cyclohexylmethyl)-2-hydroxy-4-isopropyl-5-hexenyl]-α-[(R)-α-[(dimethylcarbamoyl) methyl]hydrocinnamamido]imidazole-4-propionamide as an amorphous powder. MS: 608 (M+H)+.

Provenance & Evidence