Morpholine → HCID 53709844, compound

Participants

Reaction Steps

600 mg (2.4 mmol) of (RS)-4-(ethoxycarbonyl)-5-phenylvaleric acid in 20 ml of acetonitrile were treated with 1.06 g (2.4 mmol) of BOP, 310 mg of Hunig base and 0.21 ml of morpholine and stirred at room temperature for 1 hour and thereafter at 50° for 2 hours. After the usual working-up and chromatography on silica gel using a 10:1 mixture of methanol and chloroform as the eluting agent, there were obtained 400 mg (52%) of (RS)-α-[2-(morpholinocarbonyl)ethyl]hydrocinnamic acid ethyl ester which was used directly in the next step. MS: 319 (M+).

Provenance & Evidence