Ethanol → HCID 178456008, compound

Participants

Reaction Steps

120 mg of N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-isopropyl-5-hexenyl]-α-(α-pivaloylhydrocinnamamido)imidazole-4-propionamide in 10 ml of ethanol were hydrogenated at room temperature for 2 hours in the presence of 20 mg of palladium-on-carbon. Thereafter, the catalyst was filtered off and the solvent was evaporated under reduced pressure, to obtain (S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-isopropylhexyl]-α-[(R)-α-(3,3-dimethyl- 2-oxobutyl)hydrocinnamamido]imidazole-4-propionamide as a foam. MS: 617 (M+H)+.

Provenance & Evidence