Hydrochloric Acid → HCID 19790881, compound

Participants

Reaction Steps

3.94 g of this ester were dissolved in 20 ml of methanol and, while stirring at 0°, 1 mol equivalent and after 30 minutes a further 0.2 mol equivalents of 1N sodium hydroxide solution were added. The mixture was then stirred at room temperature for one hour, 1.2 mol equivalents of 1N hydrochloric acid (PH 4) were added portionwise, the solvent was evaporated under reduced pressure and the aqueous phase was extracted several times with methylene chloride. Drying and evaporation of the extracts yielded an oily residue which crystallized upon the addition of hexane. Recrystallization from hexane yielded N-[5-(1-t-butoxyformamido)valeryl]-β-alanine in 87% yield, melting point 70°.

Provenance & Evidence