2-Chlorobenzimidazole → (1H-Benzoimidazol-2-yl)-(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)amine

Participants

Reaction Steps

The title compound was prepared from 2-chlorobenzimidazole and 5 ,7-dimethyl-1,2,3,4-tetrahydro-1-naphthylamine (prepared by Procedure B from 5,7-dimethyl-1-tetralone) by Procedure A (60 min at 170° C. followed by 20 min at 200° C.). The product was purified by recrystallisation to give the title compound as the free base and as a mixture of enantiomers (white solid, mp 250-252° C.). MS(ES+) m/z 292 ([M+1]+, 100).

Provenance & Evidence