Sodium Hydroxide → HCID 9838514, compound

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Reaction Steps

A volume of 1.65 ml tin(IV)chloride and 0.76 g of sodium borohydride are added at 0° C. to 30 ml of 1,2-dimethoxyethane. The above-obtained oxime in a quantity of 1.5 g is added portion-wise to the above mixture, after which the reaction mixture is stirred overnight at room temperature. Then a mixture of water and a 2N NaOH solution is added while cooling on ice, after which the product is extracted with ethyl acetate. The ethyl acetate layer is treated with 2N hydrochloric acid and the product is filtered. The desired 5-aminomethyl-2,2':5',2''-terthiophene (1) is obtained, after drying, in a yield of 0.6 g; UV-abs. spectrum: λmax =355 nm, γ=20,000.

Provenance & Evidence