4-Hydroxybenzoic Acid → 4-(6-Hydroxyhexyloxy)benzoic acid

Participants

Reaction Steps

5.4 g of p-hydroxybenzoic acid was added to ethanol-dioxane mixture solvent, and an aqueous solution containing 6.6 g of potassium hydroxide was added thereto, followed by dropwise addition of 7.9 g of 6-bromohexanol and 12 hours of heat refluxing. The reaction mixture was then acidified, extracted with ethyl acetate and purified by column chromatography to obtain 5.3 g of the product (Yield: 57 %).

Provenance & Evidence