Hydrochloric Acid → 1-Propanol, 2-[(tetrahydro-2H-pyran-2-yl)oxy]-

Participants

Reaction Conditions

Reaction Steps

25.0 g of lithium aluminum hydride was suspended in anhydrous ether, and 36.7 g of the compound (5a) was added thereto, followed by stirring for 1 hour at 0° C. and 2 hours at room temperature and neutralization by addition of aqueous HCl solution at 0° C. The reaction mixture was subjected to extraction with ether and reduced pressure-distillation (60° C./0.3 mmHg) to obtain 28.0 g of the product. (Yield: 90.2 %)

Provenance & Evidence