1-(2-Methoxyphenyl)piperazine → 73438-28-5

Participants

Reaction Steps

To epichlorohydrin (3.9 ML, 50 mmol) in CH3CN (3 mL) at 0° C. was added 1-(2-methoxyphenyl)piperazine (9 mL, 50 mmol) in CH3CN (20 mL) dropwise over 5 minutes under a nitrogen atmosphere. After 16 hours the resultant white precipitate was filtered away, washed with CH3CN and acetone, dried at 30° C. in a vacuum oven and identified as pure product (7.28 g, 51.1%). mp 96°-98° C. DCI/MS M+1=285. (100 MHz) 1 H nmr (dmso-d6) δ:6.9 (m, 4H), 3.76(m, 1H), 3.76 (s, 3H), 3.62 (d of d, 2H), 2.96 (m, 4H), 2.56 (m, 6H).

Provenance & Evidence