Sodium Hydroxide → HCID 15285850, compound

HRID 1655859Notes

Reaction equation

HRID 1655859 reaction equation
Br[C:2]1[C:3]([CH2:14][P:15]([OH:18])([OH:17])=[O:16])=[N:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=2)[CH:7]=1.[OH-].[Na+]>[Pd].O>[P:15]([CH2:14][C:3]1[CH:2]=[CH:7][N:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=[C:5]2[N:4]=1)([OH:17])([OH:18])=[O:16]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 15285849HCID 15285849, compound

Product 1

HCID 15285850HCID 15285850, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

6-Bromo-7-phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid 19 (15 mg) was introduced in a 250 mL Parr bottle with 0.5N NaOH (1 mL), water (15 mL) and Pd on Carbon (5%, 20 mg). The bottle was evacuated, filled with hydrogen and shaken for one hour at room temperature. The product was purified by passing through a strongly basic ion-exchange column. The product 20 was eluted with 1N HCl.

Workup

  1. customThe bottle was evacuated
  2. additionfilled with hydrogen
  3. customThe product was purified
  4. washThe product 20 was eluted with 1N HCl

Sources & evidence

ORD record
ord-13d0937f1acb4903ac53ac14a4476671
Source dataset
uspto-grants-1993_10
Patent number
US05252563

Reaction notes

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