Sodium Methoxide → HCID 19789280, compound

HRID 1655890Notes

Reaction equation

HRID 1655890 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9]([NH:12][C:13]([C:15]1[N:16]=[C:17](Br)[S:18][CH:19]=1)=[O:14])(=[O:11])=[O:10].[CH3:21][O-:22].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9]([NH:12][C:13]([C:15]1[N:16]=[C:17]([O:22][CH3:21])[S:18][CH:19]=1)=[O:14])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 19789279HCID 19789279, compound

Product 1

HCID 19789280HCID 19789280, compoundYield 88.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.3 g of N-(2,6-dichlorophenylsulfonyl)-2-bromothiazole-4-carboxamide and 1.6 g of sodium methanolate in 45 ml of methanol are refluxed for 12 h. After cooling, the precipitate is filtered off with suction, washed with methanol and then dried under reduced pressure. 1.8 g of N-(2,6-dichlorophenylsulfonyl)-2-methoxythiazole-4-carboxamide with a melting point of 162°-165° C. are obtained. (Active ingredient Example No. 34).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with methanol
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-29e9707285a842d5810d5b903d3c56c9
Source dataset
uspto-grants-1993_10
Patent number
US05252540

Reaction notes

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