反应详情

To 10 ml of toluene were added 720 mg of the compound of Example 1 and 770 mg of phosphorus pentasulfide. The mixture was heated to reflux for 4 hours. After the mixture has been cooled, the insoluble substance was filtered off and the solvent was distilled off. The residue was purified by silica gel chromatography to give 535 mg of the title compound. The structural formula and physical data of this compound are shown in Table 23.

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 hours
3. temperatureAfter the mixture has been cooled
4. filtrationthe insoluble substance was filtered off
5. distillationthe solvent was distilled off
6. customThe residue was purified by silica gel chromatography