反应详情

温度

-30 °C

3-Carboethoxybenzyl bromide (1 ml; Heterocycles, 1977, 6, 5) was added to a saturated solution of ammonia in acetonitrile (30 ml) which had been cooled to -30° C. The mixture was stirred and allowed to warm to laboratory temperature. The mixture was filtered and the filtrate was evaporated. The residue was purified by chromatography on a silica gel column using a 10:1 v/v mixture of ethyl acetate and methanol as eluent. There was thus obtained as an oil 3-carboethoxybenzylamine (0.4 g) which was used without further purification as the appropriate amine in the process described in Example 1.

1. temperatureto warm to laboratory temperature
2. filtrationThe mixture was filtered
3. customthe filtrate was evaporated
4. customThe residue was purified by chromatography on a silica gel column
5. additiona 10:1 v/v mixture of ethyl acetate and methanol as eluent