Benzonitrile, 3-(aminomethyl)- → HCID 136102952, compound

HRID 1655948Notes

Reaction equation

[CH3:1][C:2]1[N:11](COC(=O)C(C)(C)C)[C:10](=[O:20])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:21][N:22]([C:29]3[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=3)[CH2:23][CH2:24][O:25]C(=O)C)[CH:8]=2)[N:3]=1.[C:38]([C:40]1[CH:41]=[C:42]([CH:45]=[CH:46][CH:47]=1)[CH2:43][NH2:44])#[N:39]>>[C:38]([C:40]1[CH:41]=[C:42]([CH:45]=[CH:46][CH:47]=1)[CH2:43][NH:44][C:33](=[O:34])[C:32]1[CH:31]=[CH:30][C:29]([N:22]([CH2:21][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[N:3]=[C:2]([CH3:1])[NH:11][C:10]3=[O:20])[CH2:23][CH2:24][OH:25])=[CH:37][CH:36]=1)#[N:39]

Participants

Reactant 2

HCID 457594Benzonitrile, 3-(aminomethyl)-

HCID 15079348HCID 15079348, compound

Product 1

HCID 136102952HCID 136102952, compound

Procedure

Using the procedure described in Example 10, p-[N-(3,4-dihydro-2-methyl-4-oxo-3-pivaloyloxymethylquinazolin-6-ylmethyl)-N-(2-acetoxyethyl)amino]benzoic acid was reacted with 3-cyanobenzylamine to give N-(3-cyanobenzyl)-p-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-(2-hydroxyethyl)amino]benzamide, m.p. 110°-112° C., as a foam.

Sources & evidence

ORD record: ord-d8e1186aa32f4efd8fe21f2beec73819
Source dataset: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05252573

Reaction notes

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