3-[N-(2-Phthalimidoethyl)amino]-5-methoxychroman → 2-{2-[(5-Methoxy-chroman-3-yl)-propyl-amino]-ethyl}-isoindole-1,3-dione; hydrochloride

HRID 1655975Notes

Reaction equation

HRID 1655975 reaction equation
C1(=O)N(C[CH2:7][CH2:8][CH2:9][NH:10][CH:11]2[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[O:21][CH3:22])[O:13][CH2:12]2)C(=O)C2=CC=CC=C12.[C:29]1(=[O:54])[N:33]([CH2:34][CH2:35]NC2CC3C(=CC=CC=3OC)OC2)[C:32](=[O:49])[C:31]2=[CH:50][CH:51]=[CH:52][CH:53]=[C:30]12>>[CH2:9]([N:10]([CH:11]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][C:18]=2[O:21][CH3:22])[O:13][CH2:12]1)[CH2:35][CH2:34][N:33]1[C:29](=[O:54])[C:30]2=[CH:53][CH:52]=[CH:51][CH:50]=[C:31]2[C:32]1=[O:49])[CH2:8][CH3:7]

Participants

3

Reactant 2

HCID 103159993-[N-(2-Phthalimidoethyl)amino]-5-methoxychromanHCID 104298593-[N-(4-Phthalimidobutyl)amino]-5-methoxychroman

Product 1

HCID 99779372-{2-[(5-Methoxy-chroman-3-yl)-propyl-amino]-ethyl}-isoindole-1,3-dione; hydrochlorideYield 70%

Procedure

Using the procedure described in Example 2, but replacing the compound of Example 1 by the compound of Example 5, the expected product is obtained.

Sources & evidence

ORD record
ord-a30c6db48f8d4db79caf940ea203ff72
Source dataset
uspto-grants-1993_10
Patent number
US05252578

Reaction notes

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