3-[N-Propyl-N-(4-phthalimidobutyl)amino]-5-methoxychroman → 3-{4-[N-Propyl-N-(5-methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octane

HRID 1655977Notes

Reaction equation

HRID 1655977 reaction equation
[CH2:1]([N:4]([CH:20]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][C:27]=2[O:30][CH3:31])[O:22][CH2:21]1)[CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:13](=[O:14])[C:12]2=[CH:15]C=[CH:17][CH:18]=[C:11]2[C:10]1=[O:19])[CH2:2][CH3:3].COC1C=CC=C2C=1CC(NCCCCN1C(=O)C3C(CCC3)C1=O)CO2>>[CH2:1]([N:4]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]1[C:10](=[O:19])[CH:11]2[CH:12]([CH2:15][CH2:17][CH2:18]2)[C:13]1=[O:14])[CH:20]1[CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][C:27]=2[O:30][CH3:31])[O:22][CH2:21]1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 102516733-[N-Propyl-N-(4-phthalimidobutyl)amino]-5-methoxychromanHCID 103392513-{4-[N-(5-Methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octane

Product 1

HCID 102512343-{4-[N-Propyl-N-(5-methoxy-3-chromanyl)amino]butyl}-2,4-dioxo-3-azabicyclo[3.3.0]octaneYield 78%

Procedure

Using the procedure described in Example 2, but replacing the compound of Example 2 by the compound of Example 11, the expected product is obtained.

Sources & evidence

ORD record
ord-65098a4158554ab5a5da41a2556445e1
Source dataset
uspto-grants-1993_10
Patent number
US05252578

Reaction notes

Loading…