Oxalic Acid → (4-[N-n-PROPYL-N-(5-METHOXY-3-CHROMANYL)-AMINO]BUTYL}-2,4-DIOXO-3-AZASPIRO[4.5]DECANE OXALATE

HRID 1655980Notes

Reaction equation

HRID 1655980 reaction equation
CO[C:3]1[CH:12]=CC=C2[C:4]=1CC(NCCCCN1C(=O)C3(CCCCC3)CC1=O)CO2.[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].[CH3:36][O:37][C:38]1[CH:47]=[CH:46][CH:45]=[C:44]2[C:39]=1[CH2:40][CH:41]([NH:48][CH2:49][CH2:50][CH2:51][CH2:52][CH:53]1[C:57]3([CH2:62][CH2:61][CH2:60][CH2:59][CH2:58]3)[C:56](=[O:63])[NH:55][C:54]1=[O:64])[CH2:42][O:43]2.C(O)(=O)C(O)=O>>[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].[CH2:4]([N:48]([CH2:49][CH2:50][CH2:51][CH2:52][CH:53]1[C:57]2([CH2:58][CH2:59][CH2:60][CH2:61][CH2:62]2)[C:56](=[O:63])[NH:55][C:54]1=[O:64])[CH:41]1[CH2:40][C:39]2[C:44](=[CH:45][CH:46]=[CH:47][C:38]=2[O:37][CH3:36])[O:43][CH2:42]1)[CH2:3][CH3:12]

Participants

4

Reactant 3

HCID 971Oxalic AcidHCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 131718213(4-[N-(5-Methoxy-3-chromanyl)amino]butyl}2,4-dioxo-3-azaspiro[4.5]decane oxalate

Product 1

HCID 131718212(4-[N-n-PROPYL-N-(5-METHOXY-3-CHROMANYL)-AMINO]BUTYL}-2,4-DIOXO-3-AZASPIRO[4.5]DECANE OXALATE

Procedure

Using the procedure described in Example 10, but replacing the compound of Example 9 by the compound of Example 28, the product of the title is obtained. It is salified with oxalic acid.

Workup

  1. customthe product of the title is obtained

Sources & evidence

ORD record
ord-0c2ccd34d44041b2b314d7bf0b326e4f
Source dataset
uspto-grants-1993_10
Patent number
US05252578

Reaction notes

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