(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane → (+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

HRID 1655981Notes

Reaction equation

HRID 1655981 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].CO[C:9]1[CH:18]=CC=C2[C:10]=1CC(NCCCCC1C3(CCCCC3)C(=O)NC1=O)CO2.[CH3:36][O:37][C:38]1[CH:47]=[CH:46][CH:45]=[C:44]2[C:39]=1[CH2:40][CH:41]([NH:48][CH2:49][CH2:50][CH2:51][CH2:52][N:53]1[C:57](=[O:58])[C:56]3([CH2:63][CH2:62][CH2:61][CH2:60][CH2:59]3)[CH2:55][C:54]1=[O:64])[CH2:42][O:43]2>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:10]([N:48]([CH2:49][CH2:50][CH2:51][CH2:52][N:53]1[C:57](=[O:58])[C:56]2([CH2:63][CH2:62][CH2:61][CH2:60][CH2:59]2)[CH2:55][C:54]1=[O:64])[CH:41]1[CH2:40][C:39]2[C:44](=[CH:45][CH:46]=[CH:47][C:38]=2[O:37][CH3:36])[O:43][CH2:42]1)[CH2:9][CH3:18]

Participants

3

Reactant 2

HCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 131718213(4-[N-(5-Methoxy-3-chromanyl)amino]butyl}2,4-dioxo-3-azaspiro[4.5]decane oxalate

Product 1

HCID 18966570(+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

Procedure

Using the procedure described in Example 29, but replacing the compound of Example 28 by the compound of Example 30, the product of the title is obtained.

Workup

  1. customthe product of the title is obtained

Sources & evidence

ORD record
ord-3b95f4a67fe343d1853a148d8abb9d81
Source dataset
uspto-grants-1993_10
Patent number
US05252578

Reaction notes

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