Methanol → Methyl indane-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

Dissolve 2-carboxy-indane (2.5 g, 15.4 mmol) in methanol and cool to 0° C. Saturate with hydrogenchloride gas then add 2,2-dimethoxypropane (2-3 mL). Stir overnight then evaporate the solvent in vacuo. Purify by silica gel chromatography (2:1 methylene chloride:hexane) to give 2-carbomethoxy-indane as a water white oil (2.04 g, 75%).

Provenance & Evidence