Sulfuric Acid → HCID 19789936, compound

HRID 1656043Notes

Reaction equation

HRID 1656043 reaction equation
[SH:1][CH2:2][C:3]1([C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.S(=O)(=O)(O)O.[C:24](OC(=O)C)(=[O:26])[CH3:25].C(OCC)C>C(O)(=O)C>[C:24]([S:1][CH2:2][C:3]1([C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1)(=[O:26])[CH3:25]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 10400639HCID 10400639, compound

Product 1

HCID 19789936HCID 19789936, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Mix N-[[2-(mercaptomethyl)-2,3-dihydro-1H-indene-2-yl]carbonyl]-glycine (17.8 g, 67.2 mmol) and sulfuric acid (0.3 mL of a 10% solution in acetic acid). Add acetic anhydride (6.34 mL, 67.2 mmol) over 10 minutes. Allow to cool, pour into ethyl ether and wash with water three times. Separate the organic phase, dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureAllow to cool
  2. washwash with water three times
  3. customSeparate the organic phase
  4. dry with materialdry (MgSO4)
  5. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-365d97d025a345129d7b68efce07f185
Source dataset
uspto-grants-1993_10
Patent number
US05252601

Reaction notes

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