Lithium hydroxide, monohydrate → HCID 53928063, compound

Participants

Reaction Steps

Dissolve N-[[1,2,3,4-tetrahydro-2-[[(t-butyl)thio]methyl]-2-naphthalenyl]carbonyl]-L-phenylalanine, methyl ester (158 mg, 0.36 mmol) in methanol (3 mL). Add a solution of lithium hydroxide hydrate (1 mL in water, 1 mmol) and stir at room temperature under argon overnight. Partition between 1N hydrochloric acid and methylene chloride. Separate the organic phase and extract the acidic phase with methylene chloride (2×10 mL). Combine the organic phases, dry (MgSO4) and evaporate the solvent in vacuo to give the title compound (149 mg, 97%).

Provenance & Evidence