HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → N-[[1,2,3,4-Tetrahydro-2-(mercaptomethyl)-2-naphthalenyl]carbonyl]-isoserine, benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | N-[[1,2,3,4-Tetrahydro-2-[(acetylthio)methyl]-2-naphthalenyl]carbonyl]-isoserine, benzyl ester | HCID 88127936 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[[1,2,3,4-Tetrahydro-2-(mercaptomethyl)-2-naphthalenyl]carbonyl]-isoserine, benzyl ester | HCID 88128334 | — |
Reaction Steps
Dissolve N-[[1,2,3,4-tetrahydro-2-[(acetylthio)methyl]-2-naphthalenyl]carbonyl]-isoserine, benzyl ester (882 mg, 2.00 mmol) in tetrahydrofuran (20 mL) then add NH4OH (1 mL). Stir at ambient temperature under an atmosphere of argon for 24 hours, then concentrate in vacuo. Purify the residue by column chromatography (ethyl acetate:hexane) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05252601 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-1aea0af2b8144e1890edc2b27b63e5cb |
| Source note | uspto-grants-1993_10 |