P-Cresol → HCID 19784610, compound

Participants

Reaction Steps

A mixture of 162 g (1.50 mol) of 4-methylphenol and 196.2 g (1.0 mol) of 4-ethoxymandelic acid are stirred under nitrogen for 2 hours at 140°-150° C. Stirring is then continued for 1.5 hours at 150° C. under a slight vacuum (50 mbar). Excess 4-methoxyphenol is removed by distillation under a high vacuum. Crystallisation of the residue from xylene/ethanol yields 204 g (76%) of 3-(4-ethoxyphenyl)-5-methylbenzofuran-2-one of m.p. 82°-86° C.

Provenance & Evidence