Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetamide | HCID 178 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | methyl 6-benzoyloxy-2(RS)-bromohexanoate | HCID 15222235 | — |
| Product | methyl 6-benzoyloxy-2(RS)-fluorohexanoate | HCID 15224608 | — |
| Product | Methyl 6-benzoyloxyhexanoate | HCID 19930972 | 58.3% |
Reaction Steps
A mixture of methyl 6-benzoyloxy-2(RS)-bromohexanoate (e) (14.02 g), potassium fluoride (12.59 g) and acetamide (12.3 g) was stirred at 105° C. for 6 hours. The crude product obtained by treating in the conventional manner was subjected to silica gel chromatography to give the title compound (f) and methyl 6-benzoyloxyhexanoate (g) (3.11 g, yield: 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05252605 |
|---|
| Source dataset | uspto-grants-1993_10 |
|---|
| ORD ID | ord-cc96f00392484bdda1a874034e3a6585 |
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| Source note | uspto-grants-1993_10 |
|---|
