Chloroform → HCID 22411936, compound

HRID 1656104Notes

Reaction equation

HRID 1656104 reaction equation
[C:1]1([C:7]2[NH:8][C:9]([CH3:17])=[C:10]([CH:12](O)[CH:13]([CH3:15])[CH3:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(Cl)[Cl:19]>O=S(Cl)Cl>[ClH:19].[C:1]1([C:7]2[NH:8][C:9]([CH3:17])=[C:10]([CH:12]([Cl:19])[CH:13]([CH3:15])[CH3:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6212ChloroformHCID 15067843HCID 15067843, compound

Product 1

HCID 22411936HCID 22411936, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

27 g of 2-phenyl-4-(1-hydroxy-2-methylpropyl)-5-methyl-1H-imidazole are dissolved in 700 ml of chloroform with 44 ml of SOCl2 and refluxed for 5 hours. 2-Phenyl-5-methyl-4-(1-chloro-2-methylpropyl)-1H-imidazole hydrochloride is isolated in quantitative yield.

Workup

  1. temperaturerefluxed for 5 hours

Sources & evidence

ORD record
ord-f12f0db62c0248749bd908bcf19b0027
Source dataset
uspto-grants-1993_10
Patent number
US05252736

Reaction notes

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