1,2-Dibromoethane → 1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethoxy)-

Participants

Reaction Steps

Dissolve 32.6 g of N-hydroxyphthalimide in 240 ml of dimethylformamide and introduce, into this solution, 74 g of 1,2-dibromoethane and then 40 g of triethylamine. Stir the reaction mixture at room temperature for 20 hours and then filter the crystals which have precipitated. Pour the filtrate into 1500 ml of cold water and isolate the white precipitate formed. After washing with water and drying in an oven, the product is obtained, with a 60% yield, which melts at 98° C.

Provenance & Evidence