HCID 54352100, compound → HCID 10197748, compound

Participants

Reaction Steps

A 2.93 g (12.61 mmol) sample of (2S,4S)-4-acetylamino-2-methyl-1-N-benzylpyrrolidine, from Example 1, step g above, was dissolved in 50 mL of methanol, 0.60 g of 10% Pd/C was added and the mixture shaken under 4 atm of hydrogen at room temperature for 13 hours. The mixture was concentrated, the catalyst was removed by filtration, and the solvent removed to afford 1.688 g (94.1% yield) of the title compound as a white solid. MS M/Z: 143 (M+H). NMR (CDCl3) δ: 1.16 (d, 3H, J=6 Hz), 1.63 (m, 1H), 1.79 (m, 1H), 1.95 (s, 3H), 2.65 (m, 1H), 3.28 (m, 1H), 3.41 (m, 1H), 4.40 (m, 1H), 5.81 (br, 1H).

Provenance & Evidence