HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2-Bromoethoxy)-tert-butyldimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Catalyst | 2-Dimethylaminopyridine | HCID 21885 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | 88.8% |
Reaction Steps
To a solution of 2-bromoethanol (50 g, 0.40 mol) in CH2Cl2 (50 mL) was added t-butyldimethylchlorosilane (63.4 g, 0.42 mol), triethylamine (45.4 g, 0.45 mol) and dimethylaminopyridine (0.5 g). After stirring overnight the reaction mixture was washed 3× with water. The organic fraction was dried with Na2SO4, filtered, and concentrated in vacuo to provide 85 g of the title compound as a light yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05252732 |
| Source dataset | uspto-grants-1993_10 |
| ORD ID | ord-69993f00f0534ae8ae31ae8f3d5eb24a |
| Source note | uspto-grants-1993_10 |