HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzimidazole → (1H-Benzoimidazol-2-yl)-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | 7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine | HCID 10942798 | — |
| Product | (1H-Benzoimidazol-2-yl)-(7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)amine | HCID 25157554 | — |
Reaction Steps
The title compound was prepared from 2-chlorobenzimidazole and 7-fluoro-1,2,3,4-tetrahydro-1-naphthylamine (prepared by Procedure B from 7-fluoro-1 -tetralone) by Procedure A. The product was purified by column chromatography to give the title compound as the free base and as a mixture of enantiomers (white solid, mp 181° C.). MS(ES+) m/z 282 ([M+1]+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737167B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-659f4c92bf4c415ea05c5b935dd9dae7 |
| Source note | uspto-grants-2010_06 |