Ethanol → HCID 7035705, compound

HRID 1656326Notes

Reaction equation

HRID 1656326 reaction equation
[CH2:1](O)[CH3:2].S(=O)(=O)(O)O.[C:9]([NH:17][C@H:18]([C:22]([OH:24])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[C:9]([NH:17][C@H:18]([C:22]([O:24][CH2:1][CH3:2])=[O:23])[CH:19]([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 7302905699-79-6

Product 1

HCID 7035705HCID 7035705, compoundYield 71%

Procedure

Dissolve in 100 ml of ethanol 0.045 mol (10 g) of N-benzoylvaline obtained in the preceding Step, add 5 ml of concentrated sulphuric acid, then heat at reflux for 24 hours. Evaporate to dryness, take up in ether, wash with water then with a 10% potassium bicarbonate solution, dry, filter and evaporate to dryness. Ethyl N-benzoylvalinate is obtained.

Workup

  1. customobtained in the preceding Step
  2. temperatureheat
  3. temperatureat reflux for 24 hours
  4. customEvaporate to dryness
  5. washwash with water
  6. dry with materialwith a 10% potassium bicarbonate solution, dry
  7. filtrationfilter
  8. customevaporate to dryness

Sources & evidence

ORD record
ord-f32974852f14475aa494efe18e9dd3d6
Source dataset
uspto-grants-1993_10
Patent number
US05254548

Reaction notes

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