Diethyl Ether → HCID 131718227, compound

HRID 1656341Notes

Reaction equation

HRID 1656341 reaction equation
[F:1][C:2]([C:5]1[C:6](=[O:19])[C:7]([OH:18])=[N:8][N:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:10]=1[CH3:11])([F:4])[F:3].[CH2:20]([O:22]CC)[CH3:21]>C(OC(=O)C)(=O)C>[F:3][C:2]([C:5]1[C:6](=[O:19])[C:7]([O:18][C:20](=[O:22])[CH3:21])=[N:8][N:9]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:10]=1[CH3:11])([F:1])[F:4]

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 178427868HCID 178427868, compound

Product 1

HCID 131718227HCID 131718227, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
50 °C

Procedure

A suspension of Compound 1 (2.36 grams) in acetic anhydride is heated for six hours at 50° C. The recooled solution is concentrated under vacuum. There is obtained, after the addition of diethyl ether, filtration, washing with ether and drying, the Compound 3 (1.91 grams; yield=70%).

Workup

  1. concentrationThe recooled solution is concentrated under vacuum
  2. customThere is obtained
  3. washwashing with ether
  4. customdrying

Sources & evidence

ORD record
ord-f298d74addcb43f48f88a8b09d4ec9dd
Source dataset
uspto-grants-1993_10
Patent number
US05254554

Reaction notes

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