Tetrahydrofuran → HCID 67885081, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 230 mg of 4-methoxymethyl-9-tosyl-6-triisopropylsilyloxy-beta-carboline-3-carboxylic acid isopropyl ester in 3.5 ml of absolute tetrahydrofuran was mixed at -60° C. under argon with 0.38 ml of a 1.08 molar phenyllithium solution in ether/hexane, stirred for 1 hour at -60° C. and heated slowly to room temperature. After 16 hours of standing at room temperature, the reaction mixture was mixed with N-acetic acid/ethyl acetate, the ethyl acetate phase was washed with water and saturated sodium chloride solution, dried and concentrated by evaporation. After column chromatography on silica gel with cyclohexane/ethyl acetate 1:1 as eluant, 69 mg of title compound was obtained.

Provenance & Evidence